Peer-Reviewed Research Publications: 56 (2013-Present)

Trivedi A, Bose D, Saha P, Roy S, More M, Skupsky J, Klimas NG, Chatterjee S. Prolonged Antibiotic Use in a Preclinical Model of Gulf War Chronic Multisymptom-Illness Causes Renal Fibrosis-like Pathology via Increased micro-RNA 21-Induced PTEN Inhibition That Is Correlated with Low Host Lachnospiraceae AbundanceCells. 2024 Dec 27.

More M, Chatterjee S, Saha P, Bose D, Trivedi A, Roy S, Chatterjee S. Host microbiome associated low intestinal acetate correlates with progressive NLRP3-dependent hepatic-immunotoxicity in early life microcystin-LR exposure. BMC Pharmacol Toxicol. 2023 Dec 13.

Roy, S., Saha, P., Bose, D., Trivedi, A., More, M., Xiao, S., Diehl, A.M., Chatterjee, S. Hepatic NLRP3-Derived Hsp70 Binding to TLR4 Mediates MASLD to MASH Progression upon Inhibition of PP2A by Harmful Algal Bloom Toxin Microcystin, a Second Hit. Int. J. Mol. Sci. 2023 Nov 15. 

Chatterjee S, More M. Cyanobacterial Harmful Algal Bloom Toxin Microcystin and Increased Vibrio Occurrence as Climate-Change-Induced Biological Co-Stressors: Exposure and Disease Outcomes via Their Interaction with Gut-Liver-Brain Axis. Toxins (Basel). 2023 Apr.

Bose D, Stebliankin V, Cickovski T, Saha P, Trivedi A, Roy S, More M, Tuteja A, Mathee K, Narasimhan G, Chatterjee S. Microbiome Dysbiosis Shows Strong Association of Gut-Derived Altered Metabolomic Profile in Gulf War Chronic Multisymptom Illness Symptom Persistence Following Western Diet Feeding and Development of Obesity. Int. J. Mol. Sci.2023 Feb.

Saha P, Upright M, Bose D, Roy S, Trivedi A, More M, Scott GI, Brooks BW, Chatterjee S. Subchronic Oral Cylindrospermopsin Exposure Alters the Host Gut Microbiome and Is Associated with Progressive Hepatic Inflammation, Stellate Cell Activation, and Mild Fibrosis in a Preclinical Study. Toxins (Basel). 2022 Dec.

Saha P, Bose D, Stebliankin V, Cickovski T, Seth RK, Porter DE, Brooks BW, Mathee K, Narasimhan G, Colwell R, Scott GI, Chatterjee S. Prior exposure to microcystin alters host gut resistome and is associated with dysregulated immune homeostasis in translatable mouse models. Sci Rep. 2022 Jul 7.

Bose D, Chatterjee S, Older E, Seth R, Janulewicz P, Saha P, Mondal A, Carlson JM, Decho AW, Sullivan K, Klimas N, Lasley S, Li J, Chatterjee S. Host gut resistome in Gulf War chronic multisymptom illness correlates with persistent inflammation. Commun Biol. 2022 Jun 7.

Mondal A, Saha P, Bose D, Chatterjee S, Seth RK, Xiao S, Porter DE, Brooks BW, Scott GI, Nagarkatti M, Nagarkatti P, Chatterjee S Environmental Microcystin exposure in underlying NAFLD-induced exacerbation of neuroinflammation, blood-brain barrier dysfunction, and neurodegeneration are NLRP3 and S100B dependent Toxicology. 2021 Aug 17.

Saha P, Skidmore PT, Holland LA, Mondal A, Bose D, Seth RK, Sullivan K, Janulewicz PA, Horner R, Klimas N, Nagarkatti M, Nagarkatti P, Lim ES, Chatterjee S. Andrographolide Attenuates Gut-Brain-Axis Associated Pathology in Gulf War Illness by Modulating Bacteriome-Virome Associated Inflammation and Microglia-Neuron Proinflammatory Crosstalk. Brain Sci. 2021 Jul.

Chatterjee S, Bose D, Seth R. Host gut microbiome and potential therapeutics in Gulf War Illness: A short review. Life Sci. 2021 Sep.

Sarkar S, Saha P, Seth RK, Mondal A, Bose D, Kimono D, Albadrani M, Mukherjee A, Porter DE, Scott GI, Xiao S, Brooks B, Ferry J, Nagarkatti M, Nagarkatti P, Chatterjee S. Higher intestinal and circulatory lactate associated NOX2 activation leads to an ectopic fibrotic pathology following microcystin co-exposure in murine fatty liver disease. Comp Biochem Physiol C Toxicol Pharmacol. 2020 Dec.

Al-Badrani M, Saha P, Mondal A, Seth RK, Sarkar S, Kimono D, Bose D, Porter DE, Scott GI, Brooks B, Raychoudhury S, Nagarkatti M, Nagarkatti P, Chatterjee S. Early microcystin-LR exposure-linked inflammasome activation in mice causes development of fatty liver disease and insulin resistance. Environ Toxicol Pharmacol. 2020 Nov.

Bose D, Saha P, Mondal A, Fanelli B, Seth RK, Janulewicz P, Sullivan K, Lasley S, Horner R, Colwell RR, Shetty AK, Klimas N, Chatterjee S. Obesity Worsens Gulf War Illness Symptom Persistence Pathology by Linking Altered Gut Microbiome Species to Long-Term Gastrointestinal, Hepatic, and Neuronal Inflammation in a Mouse Model. Nutrients. 2020 Sep.

Bose D, Mondal A, Saha P, Kimono D, Sarkar S, Seth RK, Janulewicz P, Sullivan K, Horner R, Klimas N, Nagarkatti M, Nagarkatti P, Chatterjee S. TLR Antagonism by Sparstolonin B Alters Microbial Signature and Modulates Gastrointestinal and Neuronal Inflammation in Gulf War Illness Preclinical Model. Brain Sci. 2020 Aug 8;10(8):532. doi: 10.3390/brainsci10080532. PMID: 32784362; PMCID: PMC7463890.

Kimono D, Bose D, Seth RK, Mondal A, Saha P, Janulewicz P, Sullivan K, Lasley S, Horner R, Klimas N, Chatterjee S. Host Akkermansia muciniphila Abundance Correlates With Gulf War Illness Symptom Persistence via NLRP3-Mediated Neuroinflammation and Decreased Brain-Derived Neurotrophic Factor. Neurosci Insights. 2020 Jul.

Mondal A, Bose D, Saha P, Sarkar S, Seth R, Kimono D, Albadrani M, Nagarkatti M, Nagarkatti P, Chatterjee S. Lipocalin 2 induces neuroinflammation and blood-brain barrier dysfunction through liver-brain axis in murine model of nonalcoholic steatohepatitis. J Neuroinflammation. 2020 Jul.

Sarkar S, Alhasson F, Kimono D, Albadrani M, Seth RK, Xiao S, Porter DE, Scott GI, Brooks B, Nagarkatti M, Nagarkatti P, Chatterjee S. Microcystin exposure worsens nonalcoholic fatty liver disease associated ectopic glomerular toxicity via NOX-2-MIR21 axis. Environ Toxicol Pharmacol. 2020 Jan.

Kimono D, Sarkar S, Albadrani M, Seth R, Bose D, Mondal A, Li Y, Kar AN, Nagarkatti M, Nagarkatti P, Sullivan K, Janulewicz P, Lasley S, Horner R, Klimas N, Chatterjee S. Dysbiosis-Associated Enteric Glial Cell Immune-Activation and Redox Imbalance Modulate Tight Junction Protein Expression in Gulf War Illness Pathology. Front Physiol. 2019 Oct.

Seth RK, Maqsood R, Mondal A, Bose D, Kimono D, Holland LA, Janulewicz Lloyd P, Klimas N, Horner RD, Sullivan K, Lim ES, Chatterjee S. Gut DNA Virome Diversity and Its Association with Host Bacteria Regulate Inflammatory Phenotype and Neuronal Immunotoxicity in Experimental Gulf War Illness. Viruses. 2019 Oct.

Albadrani M, Seth RK, Sarkar S, Kimono D, Mondal A, Bose D, Porter DE, Scott GI, Brooks B, Raychoudhury S, Nagarkatti M, Nagarkatti P, Jule Y, Diehl AM, Chatterjee S. Exogenous PP2A inhibitor exacerbates the progression of nonalcoholic fatty liver disease via NOX2-dependent activation of miR21. Am J Physiol Gastrointest Liver Physiol. 2019 Oct.

Sarkar S, Kimono D, Albadrani M, Seth RK, Busbee P, Alghetaa H, Porter DE, Scott GI, Brooks B, Nagarkatti M, Nagarkatti P, Chatterjee S. Environmental microcystin targets the microbiome and increases the risk of intestinal inflammatory pathology via NOX2 in underlying murine model of Nonalcoholic Fatty Liver Disease. Sci Rep. 2019 Jun 19;9(1):8742.

Dattaroy D, Seth RK, Sarkar S, Kimono D, Albadrani M, Chandrashekaran V, Hasson FA, Singh UP, Scappinie E, Tucker JC, Fan D, Nagarkatti M, Nagarkatti P, Diehl AM, Chatterjee S. Sparstolonin B (SSnB) attenuates liver fibrosis via a parallel conjugate pathway involving P53-P21 axis, TGF-beta signaling and focal adhesion that is TLR4 dependent.Eur J Pharmacol. 2018 Sep 5. pii: S0014-2999(18)30503-X.

Seth RK, Kimono D, Alhasson F, Sarkar S, Albadrani M, Lasley SK, Horner R, Janulewicz P, Nagarkatti M, Nagarkatti P, Sullivan K, Chatterjee S. Increasedbutyrate priming in the gut stalls microbiome associated-gastrointestinal inflammation and hepatic metabolic reprogramming in a mouse model of Gulf War Illness.  Toxicology and applied pharmacology 2018 Jul 1;350:64-77

Alhasson F, Seth RK, Sarkar S, Kimono DA, Albadrani MS, Dattaroy D, Chandrashekaran V, Scott GI, Raychoudhury S, Nagarkatti M, Nagarkatti P, Diehl AM, Chatterjee S. High circulatory leptin- mediated NOX-2-peroxynitrite-miR21 axis activate mesangial cells and promotes renal inflammatory pathology in nonalcoholic fatty liver disease. Redox Biol. 2018 Apr 7;17:1-15

Gängler S, Charisiadis P, Seth R, Chatterjee S, Makris KC. Time of the day dictates the variability of biomarkers of exposure to disinfection byproducts.  2018 Mar;112:33-40.

Chandrashekaran V, Seth RK, Dattaroy D, Alhasson F, Ziolenka J, Carson J, Berger FG, Kalyanaraman B, Diehl AM, Chatterjee S. HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease. Redox Biol.2017 Oct;13:8-19.

Alhasson F, Das S, Seth R, Dattaroy D, Chandrashekaran V, Ryan CN, Chan LS, Testerman T, Burch J, Hofseth LJ, Horner R, Nagarkatti M, Nagarkatti P, Lasley SM, Chatterjee S.  Altered gut microbiome in a mouse model of Gulf War Illness causes neuroinflammation and intestinal injury via leaky gut and TLR4 activation.PLoS One. 2017 Mar 22;12(3)

Seth RK, Das S, Dattaroy D, Chandrashekaran V, Alhasson F, Michelotti G, Nagarkatti M, Nagarkatti P, Diehl AM, Darwin Bell P, Liedtke W, Chatterjee S. TRPV4 activation of endothelial nitric oxide synthase resists nonalcoholic fatty liver disease by blocking CYP2E1-mediated redox toxicity.Free Radic Biol Med. 2017

Makris KC, Andrianou XD, Charisiadis P, Burch JB, Seth RK, Ioannou A, Picolos M, Christophi CA, Chatterjee S. Association between exposures to brominated trihalomethanes; hepatic injury and type II diabetes mellitus. Environment International. 2016.

Shamran H, Singh NP, Zumbrun EE, Murphy A, Taub DD, Mishra MK, Price RL, Chatterjee S, Nagarkatti M, Nagarkatti PS, Singh UP. Fatty acid amide hydrolase (FAAH) blockade ameliorates experimental colitis by altering microRNA expression and suppressing inflammation. Brain, Behavior and Immunity. 2016.

Dattaroy D, Seth RK, Das S, Alhasson F, Chandrashekaran V, Michelotti G, Fan D, Nagarkatti M, Nagarkatti P, Diehl AM, Chatterjee S. Sparstolonin B attenuates early liver inflammation in experimental NASH by modulating TLR4 trafficking in lipid rafts via NADPH oxidase activation. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2016.

Kaur K, Fayad R, Saxena A, Frizzell N, Chanda A, Das S, Chatterjee S, Hegde S, Baliga MS, Ponemone V, Rorro M, Greene J, Ehraheb Y, Redd AJ, Bian J, Restaino J, Norris LB, Quereshi ZP, Love BL, Brookstaver B, Georgantopoulos P, Sartor O, Raisch DW, Rao G, Lu K, Ray P, Hrusheshky W, Schulz R, Ablin R, Noxon V, Bennett CL; Southern Network on Adverse reactions (SONAR) project. Fluoroquinolone related neuropsychiatric and mitochondrial toxicity: a collaborative investigation by scientists and members of a social network. Journal of Community and Supportive Oncology. 2016. 

Singh NP, Singh UP, Rouse M, Zhang J, Chatterjee S, Nagarkatti PS, Nagarkatti M. Dietary Indoles Suppress Delayed-Type Hypersensitivity by Inducing a Switch from Proinflammatory Th17 Cells to Anti-Inflammatory Regulatory TCells through Regulation of MicroRNA. Journal of Immunology. 2016.

Alhasson F, Dattaroy D, Das S, Chandrashekaran V, Seth RK, Schnellmann RG, Chatterjee S. NKT cell modulates NAFLD potentiation of metabolic oxidative stress-induced mesengial cell activation and proximal tubular toxicity. American Journal of Physiology-Renal Physiology. 2016

Chandrashekaran V, Das S, Seth RK, Dattaroy D, Alhasson F, Michelotti G, Nagarkatti M, Nagarkatti P, Diehl AM, Chatterjee S. Purinergic receptor X7 mediated leptin induced GLUT4 function in stellate cells in non alcoholic steatohepatitis. Biochimica et Biophysica Acta. 2016.

Baig MS, Zaichick SV, Mao M, Abreu AL, Bakshi FR, Hart PC, Saqib U, Deng J, Chatterjee S, Block ML, Vogel SM, Malik AB, Consolaro ME, Christman JW, Minshall RD, Ganther BN, Bonini MG. NOS1-derieved nitric oxide promoter NF-κB transcriptional activity through inhibition of suppresor of cytokine signaling-1. Journal of Experimental Medicine. 2015.

Burch JM, Everson T, Seth RK, Wirth M and Chatterjee SExposure to Trihalomethanes and Biomonitoring for the Chronic Liver Disease Indicator, Alanine Aminotransferase, in the United States Population (NHANES 1999-2006). Science of the Total Environment. 2014.

Phani Gummadidala, Gabriel Kenne, Ananda Mondal, Dominic Bett, Sandra McFadden, Sydney Bromfield, Nora Banaszek, Michelle Velez-Martinez, Chandrani Mitra, Isabelle Mikell, Chatterjee S, and Anindya Chanda. A potential role of aflatoxin biosynthesis in the regulation of superoxide dismutation in Aspergillus parasiticus Eukaryotic Cell, 2014 (Submitted)

Narsale A, Enos R, Puppa M, Chatterjee S, Murphy AE, Fayad R, Pena M, Durstine LJ and Carson J. Role of Cachexia Progression on Liver Function in the ApcMin/+ Mouse. PLOS ONE,2014.

Das S, Seth RK, Dattaroy D, Alhasson F, Pourhoseini S, Nagarkatti M, Nagarkatti P, Michelotti GA, Diehl AM, Chatterjee S. NADPH Oxidase-Derived Peroxynitrite Drives Inflammation in Mice and Human Nonalcoholic Steatohepatitis via TLR4-Lipid Raft Recruitment. American J Pathology. 2014.

Dattaroy D, Pourhosseini S, Das S, Alhasson F, Seth RK, Nagarkatti M, Michelotti GA, Diehl AM, Chatterjee S. Micro RNA 21 inhibition of SMAD 7 enhances fibrogenesis via leptin mediated NADPH oxidase in experimental and human nonalcoholic steatohepatitis. Am J Physiol, Liver and Gastrointstinal Physiology. 2014.

Pourhoseini S, Seth RK, Das S, Dattaroy D, Kadiiska MB, Xie G, Nagarkatti M, Michelotti GA, Diehl AM, Chatterjee S. Upregulation of miR21 and repression of Grhl3 by leptin mediates sinusoidal endothelial injury in experimental nonalcoholic steatohepatitis. PlosOne. 2014.

Seth RK, Das S, Pourhoseini S, Dattaroy D, Igwe S, Basuray J, Fan D, Michelotti GA, Diehl AM, Chatterjee S. M1 Polarization bias and subsequent NASH progression is attenuated by nitric oxide donor DETA NONOate via inhibition of CYP2E1 induced oxidative stress in obese mice. J Pharmacol Exp Ther. 2014 Oct 27. pii: jpet.114.218131. [Epub ahead of print]

Jia X, Iwanowycz S, Wang J, Saaoud F, Yu F, Wang Y, Hu J, Chatterjee S, Wang Q, Fan D., Emodin attenuates systemic and liver inflammation in hyperlipidemic mice administrated with lipopolysaccharides. Exp Biol Med (Maywood). 2014 Apr 16. [Epub ahead of print]

Seth RK, Das S, Kumar A, Chanda A, Kadiiska MB, Michelotti G, Manautou J, Diehl AM and Chatterjee S. CYP2E1-Dependent and Leptin-Mediated Hepatic CD57 Expression on CD8+ve T Cells aid Progression of Environment-Linked Nonalcoholic Steatohepatitis has been received for consideration in Toxicology and Applied Pharmacology. Toxicol Appl Pharmacol. 2013 (epub ahead of print)

Das S, Seth RK, Kumar A, Kadiiska MB, Michelotti G, Diehl AM and Chatterjee S. Purinergic Receptor X7 is a Key Modulator of Metabolic Oxidative Stress- Mediated Autophagy and Inflammation in Experimental Nonalcoholic Steatohepatitis. AJP Gastrointestinal and Liver Physiology 2013 epub.

Miriyala S, Panchatcharam M, Landar A, Ramanujam M, Chatterjee S, Muthuswamy A. The janus of oxidative stress signaling in different pathophysiological conditions. Oxid Med Cell Longev. 2013 doi: 10.1155/2013/708796. Epub 2013 Jun 19.

Gomez-Mejiba SE, Zhai Z, Della-Vedova MC, Muñoz MD, Chatterjee S, Towner RA, Hensley K, Floyd RA, Mason RP, Ramirez DC. Immuno-spin trapping from biochemistry to medicine: Advances, challenges, and pitfalls. Focus on protein-centered radicals. Biochim Biophys Acta. 2013 May 2. doi:pii: S0304-4165(13)00194-3.

Seth RK, Kumar A, Das S, Michelotti G, Kadiiska MB, Diehl AM and Chatterjee S. Environmental toxin-linked nonalcoholic steatohepatitis and hepatic metabolic reprogramming in obese mice. Toxicol Sci. (2013) 134(2):291-303.

Kumar A, Ganini D, Deterding LJ, Ehrenshaft M, Chatterjee S, Mason RP. Immuno-spin trapping of heme-induced protein radicals: Implications for heme oxygenase-1 induction and heme degradation. Free Radic Biol Med. 2013 Apr.

Das S., Kumar A., Seth R., Tokar EJ., Waalkes MP., Kadiiska MB., Mason RP., Chatterjee S. Proinflammatory Adipokine Leptin Mediates Disinfection Byproduct Bromodichloromethane-induced Early Steatohepatitic Injury in Obesity. Toxicol Appl Pharmacol. 2013 Jun.

Sinha BK, Bhattacharjee S, Chatterjee S, Jiang J, Motten AG, Kumar A, Espey MG, Mason RP. Role of nitric oxide in the chemistry and anticancer activity of etoposide (VP-16,213). Chem Res Toxicol. 2013 Mar.

Chatterjee S, Ganini D, Tokar EJ, Kumar A, Das S, Corbett J, Kadiiska M, Waalkes M, Diehl AM, Mason RP. Leptin is key to peroxynitrite-mediated oxidative stress and Kupffer cell activation in experimental nonalcoholic steatohepatitis. J Hepatol. 2013 Apr.

Uehara T, Kosyk O, Jeannot E, Bradford BU, Tech K, Macdonald JM, Boorman GA, Chatterjee S, Mason RP, Melnyk SB, Tryndyak VP, Pogribny IP, Rusyn I. Acetaminophen-induced acute liver injury in HCV transgenic mice. Toxicol Appl Pharmacol. 2013 Jan 15.

Ansenberger-Fricano K, Ganini D, Mao M, Chatterjee S, Dallas S, Mason RP, Stadler K, Santos JH, Bonini MG. The peroxidase activity of mitochondrial superoxide dismutase. Free Radic Biol Med. 2013 Jan.